Increased cortical expression of two synaptogenic thrombospondins in human brain evolution. DNMT1 and AIM1 imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation. Global gene expression of the inner cell mass and trophectoderm of the bovine blastocyst. Elephant transcriptome provides insights into the evolution of eutherian placentation. Evolution of gene regulatory networks controlling body plan development. Gene regulatory networks and the evolution of animal body plans. CORTECON: a temporal transcriptome analysis of in vitro human cerebral cortex development from human embryonic stem cells. Comparison of early nerve cord development in insects and vertebrates.

Gene regulatory networks in the evolution and development of the heart. Control of cardiac development by an evolutionarily conserved transcriptional network. Manto, M., Schmahmann, J., Rossi, F., Gruol, D. in Handbook of the Cerebellum and Cerebellar Disorders (eds. Gene regulatory networks governing pancreas development. EMAGE mouse embryo spatial gene expression database: 2014 update. The mouse Gene Expression Database (GXD): 2014 update. Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa. Distinctive chromatin in human sperm packages genes for embryo development. Bivalent chromatin marks developmental regulatory genes in the mouse embryonic germline in vivo. A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis. Lesch, B.J., Dokshin, G.A., Young, R.A., McCarrey, J.R. Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci. Epigenetic temporal control of mouse Hox genes in vivo. Chromatin signatures of pluripotent cell lines. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Enhancer evolution across 20 mammalian species. Evolutionary changes in promoter and enhancer activity during human corticogenesis. The evolution of lineage-specific regulatory activities in the human embryonic limb. The evolutionary significance of cis-regulatory mutations. Evolution at two levels in humans and chimpanzees. Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. Epigenetic patterns maintained in early Caenorhabditis elegans embryos can be established by gene activity in the parental germ cells. Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.

Quantitative dynamics of chromatin remodeling during germ cell specification from mouse embryonic stem cells. Chromatin remodelling and epigenetic features of germ cells. We propose that critical regulators of animal development gained an epigenetically privileged state in germ cells, manifested in amniotes by H3K4me3/H3K27me3 poising, early in metazoan evolution. We find that core genes poised in germ cells from multiple amniote species are ancient regulators of morphogenesis that sit at the top of transcriptional hierarchies controlling somatic tissue development, whereas genes that gain poising in germ cells from individual species act downstream of core poised genes during development in a species-specific fashion. We examined the poised (H3K4me3/H3K27me3 bivalent) epigenetic state in male germ cells from five mammalian and one avian species. Here we assess the relationship between evolution of chromatin state in germ cells and evolution of gene regulatory programs governing somatic development. Changes in gene regulation frequently underlie changes in morphology during evolution, and differences in chromatin state have been linked with changes in anatomical structure and gene expression across evolutionary time.

Code chicken core 10.7